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Index > Protein center > Gpx4(Gene name) > Mouse
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  • Gpx4 (Gene name),
  • Phospholipid hydroperoxide glutathione peroxidase, mitochondrial (Protein name ),  GPX41_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Gpx4;
    Protein name:
    Phospholipid hydroperoxide glutathione peroxidase, mitochondrial(PHGPx);
    Alternative:
    Glutathione peroxidase 4(GPx-4;GSHPx-4);
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Monomer.
    Function:
    Protects cells against membrane lipid peroxidation and cell death. Isoform mitochondrial is required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage.
    Subcellular Location:
    Mitochondrion Cytoplasm
    Protein Attributes:
    Sequence length:
    197
    Sequence:
    50:
    MSWGRLSRLL | KPALLCGALA | APGLAGTMCA | SRDDWRCARS | MHEFSAKDID | 
    100:
    GHMVCLDKYR | GFVCIVTNVA | SQUGKTDVNY | TQLVDLHARY | AECGLRILAF | 
    150:
    PCNQFGRQEP | GSNQEIKEFA | AGYNVKFDMY | SKICVNGDDA | HPLWKWMKVQ | 
    197:
    PKGRGMLGNA | IKWNFTKFLI | DKNGCVVKRY | GPMEEPQVIE | KDLPCYL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    SMR:
    Pfam:
    UniGene:
    Uniprot:
     
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    ELISA Kit for Mouse PHGPx
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    ELISA Kit for Mouse PHGPx
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    ELISA Kit for Mouse PHGPx
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    ELISA Kit for Mouse PHGPx
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    CLIA Kit for Mouse PHGPx
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    U9951m
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    CLIA Kit for Mouse PHGPx
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    CLIA Kit for Mouse PHGPx
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    CLIA Kit for Mouse PHGPx
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    CLIA Kit for Mouse PHGPx
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    U9951m
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    CLIA Kit for Mouse PHGPx
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    U9951b
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    CLIA Kit for Mouse PHGPx
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    U9951p
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    Polyclonal Antibody for Mouse PHGPx
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    P9951Rb-h
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    Polyclonal Antibody for Mouse PHGPx
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    Polyclonal Antibody for Mouse PHGPx
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    Polyclonal Antibody for Mouse PHGPx
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    Polyclonal Antibody for Mouse PHGPx
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    Packing:
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    Polyclonal Antibody for Mouse PHGPx
    Polyclonal Antibody for Mouse PHGPx
    Monoclonal Antibody for Mouse PHGPx
    Monoclonal Antibody for Mouse PHGPx
    Monoclonal Antibody for Mouse PHGPx
    Monoclonal Antibody for Mouse PHGPx
    Monoclonal Antibody for Mouse PHGPx
    Monoclonal Antibody for Mouse PHGPx
    Monoclonal Antibody for Mouse PHGPx
    Protein for Mouse PHGPx
    Protein for Mouse PHGPx
    Protein for Mouse PHGPx
    Protein for Mouse PHGPx
    Protein for Mouse PHGPx
    Protein for Mouse PHGPx
    Protein for Mouse PHGPx

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    References
    1. 1.
      "Cloning and sequencing of the cDNA encoding a phospholipid hydroperoxide glutathione peroxidase."
      Nam S.-Y. , Nakamuta N. , Kurohmaru M. , Hayashi Y.
      Gene198:245-249(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      strain: CD-1.
      tissue: Testis.
    2. 2.
      "Cloning of the mouse phospholipid hydroperoxide glutathione peroxidase gene."
      Borchert A. , Schnurr K. , Thiele B.J. , Kuehn H.
      FEBS Lett.446:223-227(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
      strain: C57BL/6N.
    3. 3.
      "Murine phospholipid hydroperoxide glutathione peroxidase: cDNA sequence, tissue expression, and mapping."
      Knopp E.A. , Arndt T.L. , Eng K.L. , Caldwell M. , LeBoeuf R.C. , Deeb S.S. , O'Brien K.D.
      Mamm. Genome10:601-605(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]
      strain: BALB/c.
      strain: C57BL/6J.
      tissue: Myocardium.
      tissue: Testis.
    4. 4.
      "Early embryonic lethality caused by targeted disruption of the mouse PHGPx gene."
      Imai H. , Hirao F. , Sakamoto T. , Sekine K. , Mizukura Y. , Saito M. , Kitamoto T. , Hayasaka M. , Hanaoka K. , Nakagawa Y.
      Biochem. Biophys. Res. Commun.305:278-286(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
      strain: 129/SvJ.
      tissue: Liver.
    5. 5.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Testis.
    6. 6.
      "The selenoprotein GPX4 is essential for mouse development and protects from radiation and oxidative damage insults."
      Yant L.J. , Ran Q. , Rao L. , Van Remmen H. , Shibatani T. , Belter J.G. , Motta L. , Richardson A. , Prolla T.A.
      Free Radic. Biol. Med.34:496-502(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    7. 7.
      "Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death."
      Seiler A. , Schneider M. , Foerster H. , Roth S. , Wirth E.K. , Culmsee C. , Plesnila N. , Kremmer E. , Raadmark O. , Wurst W. , Bornkamm G.W. , Schweizer U. , Conrad M.
      Cell Metab.8:237-248(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;FUNCTION
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;FUNCTION;TISSUE SPECIFICITY
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